Non-steroidal anti-inflammatory drugs (NSAIDs) enter the environment during their production, use, and disposal, thereby threatening aquatic ecosystems. They represent a significant environmental issue because they are not effectively removed by conventional methods used in wastewater treatment plants. Therefore, it is necessary to develop new methods for wastewater treatment. Adsorption stands out as an efficient, economical, environmentally friendly, and simple method. Modified natural minerals, such as clays (bentonite, kaolin) and zeolites, have shown high efficiency in removing NSAIDs from aquatic environments, offering a potential solution to this problem. This paper presents a review of research results on the removal of NSAIDs using bentonites modified with various surfactants.