Refrigerant gases are widely used today, from refrigeration devices for storage, air conditioning of facilities (from households to industrial facilities) to transport cooling and air conditioning in vehicles. Considering their widespread use, it is necessary to analyze their impact on climate change. Refrigerant gases, their application and impact on GWP (Global warming potential) and ODP (Ozone depletion potential) are presented in this paper. The paper shows the division of refrigerant gases according to their chemical composition and elements that affect the damage to the ozone layer and global warming with the greenhouse effect (GHG Greenhouse gases).