The anticipation of digital e-business technologies must basically rely on an expert assessment of elements of global business, the current state of e-business infrastructure, as well as elements of development tendencies and trends of business. The infrastructure of an e-business system is a set of platforms, networks, applications, as well as data and business rules for managing internal and external business processes and is based on Internet technologies (cloud computing, internet of things, big data, ubiquitous computing), which all together lead to rapid changes in business processes and influence the more efficient functioning and development of innovative business models. On the other hand, today effective global business can be viewed through important components of work and business, such as the coexistence of traditional and digital sectors and the diffusion and implementation of innovative production technologies, with the tendencies of applied automation, flexible organizational innovations and the generating and inclusion of innovative materials and the circular economy, as well as the trends of quantitative-qualitative integration of human resources, smart specializations, flexible exploitation of technical textiles, consistent "cluster strategies" and efficient integration into the global market (with "elements of state protectionism"), etc., and on which the generating of globally adaptive, prosperous and intensively competitive companies is based. In addition to all the aforementioned elements, which are the basis of digital technology adoption in e-business, the adoption should also be viewed through the aspects of the development of the Internet of intelligent devices, context-aware computing, as well as the concept of augmented reality (which indicates an increasing adaptation to the characteristics of the environment), i.e. the basis of perhaps the key factors of the future development of e-business - the integration of artificial intelligence - AI and robotic automation - RPA. To the aforementioned elements, which are still applied to a certain extent today, anticipation must of course adequately consider, adopt and add the perfected elements of the big data segment, modern dynamic architecture of information systems,& elements of platforms without code (as a new era of inclusive digital empowerment), concepts of programmability of computer networks or so-called software-defined networks - SDN, as well as advanced analytics (through proactive strategies) and sustainability (through so-called hybrid and energy-efficient computing). The work presents the most important elements of the current infrastructure of e-business, as well as the analysis of trends and tendencies of the work and development of the technical-technological segment, as the basis of effective anticipation of digital technologies of e-business, with special reference to the needs and application in the textile and clothing industry.