Introduction and objective: Community-acquired pneumonia pneumonia is acute respiratory infection of the lung parenchyma and alveolar apparatus caused by respiratory viruses, bacteria and fungi present at all ages. It can be lobar or multilobar, unilateral or bilateral. The aim of the research is to examine the difference in disease severity and laboratory analyzes in patients with lobar and multilobar pneumonia. Methods: The retrospective study included 80 patients with symptoms and signs of acute respiratory infection who were initially examined in the Emergency Department and then treated in the hospital at the Clinic for Pulmonology, UKCS due to radiographically verified lobar or multilobar pneumonia. Demographic characteristics of patients, PCR respiratory panel of nasopharyngeal swab, radiographic topography of pneumonia, length of hospitalization, laboratory tests, therapy and pneumonia severity score (CURB65) were analyzed. Results: The average age of the patients was 67.21±69.5 years, and 43(53%) were male and 37(47%) were female. Out of the total number of patients, 24(30%) were non-smokers, the other 56(70%) were active or former smokers. The most common comorbidities are: arterial hypertension 49(61%), diabetes mellitus 15(18%), COPD 14(17%), malignancy 13(16%), cardiomyopathy 4(5%). PCR respiratory panel of nasopharyngeal swab revealed the following pathogens: Streptococcus pneumoniae 41(51%), Influenza A 25(31%), influenza virus H1N1 14(18%), Moraxella catarrhalis 8(10%), SarsCov-2 virus 6(7%). Lobar pneumonia in 39(48%) patients, more common in males 22(56%), radiographically most commonly affected lower right lobe 18(46%), average length of hospitalization 12.48±10 days, most often caused by Streptococcus Pneumoniae 20(51%) , Influenza A 13(33%), Metapneumovirus and Moraxella catharralis 3(7%) with an average inflammation marker 148.05±136, procalcitonin 13.83±0.44 and mean CURB65 values 2.15. Multilobar pneumonia in 41(52%) patients, more common in men 21(53%), average length of hospitalization 12.53±10 days, most often caused by Streptococcus Pneumoniae 22(56%), Influenza A 9(21%), SarsCov-2 virus 6(14%) with average inflammation marker 162.35±136, procalcitonin 7.25±0.44 and mean CURB65 values 2.43. 22 patients(17%) were treated in the intensive care unit with an average CURB65 score of 2.5. Fatal outcomes occurred in 16(20%) patients with an average CURB65 score of 3. CURB65 score 4-5, which indicates a high degree of mortality in the next 30 days, was present in 9(11%) patients. Conclusion: The test results are in favor of a more frequent presence of multilobar pneumonia in males, caused by the bacterium Streptococcus Pnuemoniae with higher inflammation parameters and CURB65 values, a more severe clinical picture.