The appearance of different, local, or broader epidemics was frequent in Serbia during peacetime, especially during the war years. For decades, historical science and the history of medicine paid great attention to the outbreak of three combined types of typhus: spotted, relapsing, and typhoid from the first half of 1915, and only recently to the consequences of the Spanish fever pandemic, specifically its second wave from the end of 1918, while other epidemics have been neglected. This work aims to indicate the occurrence and consequences of those other epidemics, with noticeable mortal consequences, which were observed in Serbia during the years of the First World War, but also their occurrence in the previous, pre-war years. The research is a case study based on a random sample selected according to the availability of primary historical sources, namely church death registers. The situation was analyzed in a part of the territory of western Serbia, in five church parishes of the Valjevo and Užice districts, with 26 rural settlements in which 16,039 inhabitants were registered in 1910. It was there during the eight-year period 1911-1918. a total of 4,522 inhabitants died, of which more than half - 2,620 - were caused by various epidemic diseases. The largest number of victims - 826 - was claimed by the aforementioned large epidemic of three combined typhus types from the first half of 1915. The second wave of the Spanish fever pandemic, from the very end of 1918, claimed 530 lives. The rest were victims of other local epidemics of diphtheria (244), scarlet fever (205), whooping cough (188), as well as smallpox, dysentery and typhoid fever, which occurred with similar mortality in pre-war (1911-1913) and wartime (1914-1918) periods.